The high-entropy alloy (HEA) MoNbTaVW system was studied through ab initio density
functional theory (DFT) method and weighted random body centered cubic structure (BCC) models. The bulk modulus is calculated through Birch-Murnaghan equation of states fitting. The three simulation models studied give a weighted bulk modulus 232 GPa. Besides major metallic bonding in the bulk alloy, weak partial covalent bonding are found at Mo-Nb, Nb-Ta, Nb-V, Ta-V and Mo-Nb interatomic bondings. Bader charge analysis from the three models simulation shows that the W and Mo atoms are gaining electrons from Ta and V atoms while Nb atom has minor charge transfer, close to neutral atom. Our simulations confirm the accuracy of the DFT method on alloy simulation and lay a solid base for thermal dynamics simulation and 3D laser printing research.